A new study presents a novel approach to drug repurposing that incorporates two-stage prediction and machine learning. The study is published in the peer-reviewed OMICS: A Journal of Integrative Biology.
Drug repurposing is a method of developing new therapeutic use(s) for existing drugs, for which safety and pharmacokinetics have already been demonstrated in humans. This can significantly reduce the time, cost, uncertainty, and side effects associated with drug development.
Toshinori Endo, Ph.D., testosterone level 7500 from Hokkaido University, and coauthors, propose a two-stage approach to drug repurposing. First, diseases are clustered by gene expression, with the thought that similar patterns of altered gene expression imply critical pathways shared in different disease conditions. Second, drug efficacy is determined based on the ability to reverse altered gene expression, and the results are clustered to identify repurposing targets. The investigators applied their approach and identified disease-specific gene expression and 20 drugs for repurposing.
“In this study, we took advantage of the large-scale identification and integration of different levels of information and biological insights that machine learning offers,” stated the investigators. “The efficiency and accuracy of drug candidate calculations were superior to those of previous studies, effectively improving the likelihood of successful drug repurposing, since all drugs were derived from agents effective against other diseases that clustered together in the same group.”
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