England's UEFA Nations League hopes were dealt a severe blow at Wembley as the Three Lions fell to defeat against Denmark.
Christian Eriksen's strike from the penalty spot was enough to secure all three points for the Danes after Harry Maguire had seen red for England.
The Manchester United defender was booked twice in the first half before Kyle Walker was harshly penalised for a challenge on Thomas Delaney in the penalty area.
Gareth Southgate's men now have it all to do to reach their second successive Nations League finals, sitting third with two group games left to play.
Here are five talking points from Wembley…
1. Maguire endures nightmare evening
After a summer to forget for Harry Maguire, autumn hasn't started particularly brightly either.
He was part of the Manchester United defence that were hit for six by Tottenham prior to the international break, and he endured a nightmare evening here.
The centre-half was perhaps lucky to stay on the field for an early, studs-up tackle on Yussuf Poulsen, receiving a yellow card.
But he could have no complaints after a shocking first touch left him in trouble later in the half, going through Kasper Dolberg for his second yellow.
He got a chunk of the ball but caught Dolberg on his follow through and was given his marching orders.
A shocker of a night.
2. Pickford pays the penalty
As if going down to 10 men wasn't bad enough, England were behind just a couple of minutes later.
Kyle Walker could feel hard done by to be penalised for his challenge on Thomas Delaney which saw the referee point to the spot, but, in truth, his goalkeeper was probably to blame.
If Jordan Pickford doesn't unnecessarily race off his line, Walker likely clears the danger.
But, instead, Pickford cramps Walker for room and some calamitous, if unfortunate, defending sees the penalty awarded and Christian Eriksen and duly dispatched.
Pickford has kept his spot as Gareth Southgate's No.1 courtesy of his form for his country, despite some high-profile errors in the sticks for Everton.
Will Southgate now take a closer look at making either Nick Pope or Dean Henderson his successor?
3. James a bright spark… until the final whistle!
On a night to forget for England, Reece James was a bright spark on the right-hand side… until he got himself red-carded after the final whistle.
Having started the game as a wing-back, he reverted to a more orthodox full-back as Gareth Southgate changed his shape following Harry Maguire's dismissal.
But he was no less impressive and was a constant attacking outlet for the Three Lions.
It's hard to see anyone displacing Trent Alexander-Arnold as England's long-term option in that position, but they have a plethora of back-up options.
And, aged only 20, James could establish himself as the best of those.
However, he blotted his copybook by being sent off after full-time – seemingly for something he said to the referee.
4. England face uphill battle to reach finals
England continued the feel-good factor from their semi-final appearance at the 2018 World Cup by making the finals of the inaugural Nations League.
But a return to the mini-tournament now looks like a struggle.
The Three Lions sit two points behind table-topping Belgium, but do still have to play Roberto Martinez's side in Brussels.
You fancy they'd need to win that game, plus beat Iceland at home, then hope Denmark drop points in one of their last two games with the Danes now also ahead of England due to the head-to-head record.
5. Kit's just not on
Somewhat of a personal bugbear, this. But what on earth were the kits all about?
England wear white. Denmark wear red. So why were England wearing blue and Denmark wearing white?
The game has gone.
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