Manchester United boss Ole Gunnar Solskjaer has ruled both Anthony Martial and Edinson Cavani out of Tuesday's must-not-lose Champions League clash at RB Leipzig.
Both forwards suffered injuries in Saturday's 3-1 win over West Ham in the Premier League, with Cavani replaced by Marcus Rashford at half-time and Martial withdrawn for Juan Mata just after the hour mark.
Solskjaer says the pair have just "minor niggles" but neither are fit enough to make the trip to Germany.
United need a point to secure qualification for the last-16 of the Champions League, but they will drop down to the Europa League should they lose to the Bundesliga side.
In the absences of both Martial and Cavani, Solskjaer is likely to give Mason Greenwood a start after he scored at West Ham.
“Mason is a very talented forward, one of the best I have worked with," said the Norwegian.
"He creates chances for himself and we have a great chance of scoring goals.
“He will only improve with people around the team and it is exciting to work with him.”
On the trip to Leipzig, he added: "Knockout games, or games like this, they are big.
"The players are here. They are United players because they have the qualities which we looked for.
“These are the games we look forward to. We never make it easy for ourselves! We do make it hard for ourselves, that has been ever since I played.”
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